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Gene Ontology
This web page was produced as an assignment for Genetics 564, an undergraduate capstone course at UW-Madison.
What is Gene Ontology?
Biological Processes of AQP2
Molecular functions of AQP2
Cellular Component of AQP2
Discussion
The role of AQP2 in transporting water has been well established for many years, but more recent molecular insight into how water moves through the protein has been gained(2,3). There is some evidence that mercury ions affect AQP2 activity, but its role in the cellular response to mercury remains unclear(4). AQP2 is trafficked within the endomembrane system prior to arrival at the plasma membrane, and trafficking is controlled by phosphorylation state at various serine residues at AQP2's C terminus(5,6).
References
1. Aquaporin-2. http://amigo.geneontology.org/amigo/gene_product/UniProtKB:P41181. Accessed May 6, 2017.
2. Deen, P. M. T., Croes, H., Vanaubel, R., Ginsel, L. A., & Vanos, C. H. (1995). Water channels encoded by mutant aquaporin-2 genes in nephrogenic diabetes-insipidus are impaired in their cellular routing. Journal of Clinical Investigation, 95(5), 2291-2296.
3. Padhi, S., & Priyakumar, U. D. (2017). Microsecond simulation of human aquaporin 2 reveals structural determinants of water permeability and selectivity. Biochimica Et Biophysica Acta-Biomembranes, 1859(1), 10-16.
4. Mulders, S. M., Rijss, J. P. L., Hartog, A., Bindels, R. J. M., VanOs, C. H., & Deen, P. M. T. (1997). Importance of the mercury-sensitive cysteine on function and routing of AQP1 and AQP2 in oocytes. American Journal of Physiology-Renal Physiology, 273(3), F451-F456.
5. Arnspang, E. C., Login, F. H., Koffman, J. S., Sengupta, P., & Nejsum, L. N. (2016). AQP2 Plasma Membrane Diffusion Is Altered by the Degree of AQP2-S256 Phosphorylation. International Journal of Molecular Sciences, 17(11). doi:10.3390/ijms17111804
6. Jung, H. J., & Kwon, T. H. (2016). Molecular mechanisms regulating aquaporin-2 in kidney collecting duct. American Journal of Physiology-Renal Physiology, 311(6), F1318-F1328. doi:10.1152/ajprenal.00485.2016
2. Deen, P. M. T., Croes, H., Vanaubel, R., Ginsel, L. A., & Vanos, C. H. (1995). Water channels encoded by mutant aquaporin-2 genes in nephrogenic diabetes-insipidus are impaired in their cellular routing. Journal of Clinical Investigation, 95(5), 2291-2296.
3. Padhi, S., & Priyakumar, U. D. (2017). Microsecond simulation of human aquaporin 2 reveals structural determinants of water permeability and selectivity. Biochimica Et Biophysica Acta-Biomembranes, 1859(1), 10-16.
4. Mulders, S. M., Rijss, J. P. L., Hartog, A., Bindels, R. J. M., VanOs, C. H., & Deen, P. M. T. (1997). Importance of the mercury-sensitive cysteine on function and routing of AQP1 and AQP2 in oocytes. American Journal of Physiology-Renal Physiology, 273(3), F451-F456.
5. Arnspang, E. C., Login, F. H., Koffman, J. S., Sengupta, P., & Nejsum, L. N. (2016). AQP2 Plasma Membrane Diffusion Is Altered by the Degree of AQP2-S256 Phosphorylation. International Journal of Molecular Sciences, 17(11). doi:10.3390/ijms17111804
6. Jung, H. J., & Kwon, T. H. (2016). Molecular mechanisms regulating aquaporin-2 in kidney collecting duct. American Journal of Physiology-Renal Physiology, 311(6), F1318-F1328. doi:10.1152/ajprenal.00485.2016